![]() ![]() We confirmed that Th17 cells, which are characterized by the production of interleukin-17, are a characteristic feature of myocardial injury in the acute phase of myocarditis. ![]() We then identified a human noncoding RNA with high sequence similarity to mmu-miR-721 (we infer it to be a homologue) and compared its expression in plasma obtained from patients with acute myocarditis with the expression in various controls. We also performed RT-qPCR in samples from coxsackievirus-induced myocarditis in mice. To identify a microRNA specific for myocarditis, we performed microRNA microarray analyses and reverse-transcriptase–quantitative polymerase-chain-reaction (RT-qPCR) assays in sorted CD4+ T cells and type 17 helper T (Th17) cells after inducing experimental autoimmune myocarditis or myocardial infarction in mice. We sought to identify a novel microRNA for the diagnosis of acute myocarditis. ![]() Additional approaches to diagnosis are desirable. The diagnosis of acute myocarditis typically requires either endomyocardial biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not universally available). ![]() Original Article A Novel Circulating Noncoding Small RNA for the Detection of Acute Myocarditis List of authors. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. ![]()
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